Publications

28. Development of separation technology for targeted thorium conjugate formulations. Part II, Sequential DOE, MLR, PLS

Development of separation technology for the removal of radium-223 from targeted thorium conjugate formulations. Part II: purification of targeted thorium conjugates on cation exchange columns Janne Olsen Frenvik, Knut Dyrstad, Solveig Kristensen & Olav B. Ryan To cite this artic
Read More

27. Development of Separation Technology for Thorium-227 Conjugate Formulations Part I, DoE, MLR, PLSR

Development of Separation Technology for the Removal of Radium-223 from Targeted Thorium Conjugate Formulations Part I: Purification of Decayed Thorium-227 on Cation Exchange Columns. Janne Olsen Frenvik, Knut Dyrstad, Solveig Kristensen & Olav B. Ryan Published in: Drug Developm
Read More

26. PET Alzheimer agent, formulation, polysorbate solubilser, DoE, MCR, PLSR

The Influence of Polysorbate 80 on the Radiochemical Synthesis of a PET Tracer in the FASTlab Wai Lam Yip, Sverre Arne Sande, David Grace, Dirk Jan In t Veld, Per Christian Sontum, Tina Solvang, Knut Dyrstad Pharm Res 2014 Oct 31. Epub 2014 Oct 31.
Read More

25. Raw material classification by NIR, PCA, MIPCR, PLS-DA

Classification of structurally related commercial contrast media by near infrared spectroscopy. Wai Lam Yip, Tom Collin Soosainather, Knut Dyrstad, Sverre Arne Sande Journal of Pharmaceutical and Biomedical Analysis (2013)  
Read More

24. Freeze-drying, crystallization, water content, NIR, PLSR, MIPCR

Strategies for multivariate modelling of moisture content in freeze-dried mannitol-containing products by near-infrared spectroscopy. Wai Lam Yip, Ingvil Gausemel, Sverre Arne Sande, Knut Dyrstad Journal of Pharmaceutical and Biomedical Analysis (2012)
Read More

23. Polysorbate oxidation and stability, LC-MS, MR, DoE

Characterization of polysorbate 80 with liquid chromatography mass spectrometry and nuclear magnetic resonance spectroscopy: Specific determination of oxidation products of thermally oxidized polysorbate 80. Erlend Hvattum, Wai Lam Yip, David Grace, Knut Dyrstad Journal of Pharmaceuti
Read More

22. US contrast agent, carbohydrate bubbles, QSAR, PLSR

Stabilization of gas bubbles released from water-soluble carbohydrates using amphiphilic compounds: Preparation of formulations and acoustic monitoring of bubble lifetime. Hoff, L. , Foss, P.A., Dyrstad, K., Klaveness, J., Rongved, P. Journal of Surfactants and Detergents (2011)
Read More

21. PET agent preparation, robustness of 18F-labelling, DoE, MLR

A critical study on borosilicate glassware and silica-based QMA’s in nucleophilic substitution with [18F]fluoride: Influence of aluminum, boron and silicon on the reactivity of [18F]fluoride. Svadberg, A., Clarke, A., Dyrstad, K., Martinsen, I., Hjelstuen, O.K. Applied Radiation
Read More

20. PET, 18F incorporation, DoE, MLR

Site-specific addition of an18F-N-methylaminooxy-containing prosthetic group to a vinylsulfone modified peptide. Olberg, D.E., Hjelstuen, O.K., Solbakken, M., Arukwe, J.M., Dyrstad, K., Cuthbertson, A. Journal of Labelled Compounds and radiopharmaceuticals (2009)
Read More

19. Chemometrics, two-layer (inner, outer) cross validation, PLSR

Reducing over-optimism in variable selection by cross-model validation. Anderssen, E., Dyrstad, K., Westad, F., Martens, H. Chemometrics and Intelligent Laboratory Systems (2006).
Read More

18. Liposomes, controlled release, PLSR

Tuning the MR properties of blood-stable pH-responsive paramagnetic liposomes. Løkling, K.-E., Skurtveit, R., Dyrstad, K., Klaveness, J., Fossheim, S.L. Int. J. Pharm. (2004).
Read More

17. Preparation of pectin pellets, QSAR, PCA, DoE, PLSR

Quantum chemical descriptors in the formulation of pectin pellets produced by extrusion/spheronisation. Tho, I., Anderssen, E., Dyrstad, K., Kleinebude, K, Sande, S.A. Eur. J. Pharm. Sci. (2002).
Read More

16. Freeze-drying, water content, NIR, PLSR

Sensitive NIRS measurement of increased moisture in stored hygroscopic freeze dried product. A. Stokvold, K. Dyrstad, F.O. Libnau. Journal of Pharmaceutical and Biomedical analysis (2002).
Read More

15. Formulation development strategy for multivariat kinetic responses, classification, Weibull, PCA, SIMCA

A formulation development strategy for multivariat kinetic responses. S.A. Sande, K. Dyrstad. Drug Development and Industrial Pharmacy (2001).
Read More

14. Development of pectin matrix tablets for colonic delivery of model drug ropivacain, DoE, PLSR

Development of pectin matrix tablets for colonic delivery of model drug ropivacain. Ahrabi, S.F., Madsen, G, Dyrstad, K., Sande, S.A., Graffner, C. Eur. J. Pharm. Sci. (2000).
Read More

13. Preparation of polymeric microcapsules: Formulation studies, DoE, MLR, PLSR

Preparation of polymeric microcapsules: Formulation studies. K. Bjerknes, K. Dyrstad, G. Smistad, I. Agerkvist Drug Dev. and Ind. Pharm. (2000).
Read More

12. Polymeric particles and expected properties by a PLSR score

A chemometrics method for separation of size dependent and size independent attributes of microspheres for medical ultrasound imaging. Dyrstad, k., Sontum, P.C. and Hoff, L. J. of Microencapsulation (2000).
Read More

11. US contrast agents, air-content, PCR

Determination of air-content in protein microspheres. Kvåle, S., Dyrstad, K., Sontum, P. C and Asbjørnsen, O.A. Pharmaceutical Research (1999).
Read More

10. US contrast agents, theoretical vs empirical US properties, PLSR

Acoustics properties of NC100100 and their relationship with the microbubble size distribution. Sontum, P. C., Østensen, J., Dyrstad, K. and Hoff, L. Investigative Radiology (1999).
Read More

9. Drug stability, kinetics, stability prediction, PLSR

A multivariate method to predict the water vapor diffusion through polypropylene packaging. K. Dyrstad, J. Veggeland and C. Thomassen. Int. J. Pham. (1999).
Read More

8. Drug stability, kinetics, stability prediction, PLSR

An Opportunistic Stability Strategy; Simulation with Real Data.  K. Dyrstad, C. Thomassen and K. Eivindvik. Int. J. Pham. (1999).
Read More

7. Drugs, multiquality optimization, rotated PCA, Varimax, HK, VMR, VPLSR

Selective improvements in multiquality products assisted by rotated principal components. K. Dyrstad. Chemometrics and Intelligent Laboratory Systems (1998).
Read More

6. US contrast agents, drug efficiency, particles, PLSR

Effect of Microsphere Size Distribution on the Ultrasonographic Contrast Efficacy of Airfilled Albumin Microspheres in Dog Hearts. P.C. Sontum, P. Walday, K. Dyrstad, S. Frigstad and C. Christiansen. Investigative Radiology (1997).
Read More

5. US contrast agents, drug efficiency, particles, PLSR

Relationship between size of injected microspheres and ultrasound imaging of heart by PLSR.  K. Dyrstad and P.C. Sontum. Pharmaceutical Research (1997).
Read More

4. Optimization of a Production Process from the In-vivo Response of a Diagnostical Drug, PAT, PLSR

Optimization of a Production Process from the In-vivo Response of a Diagnostical Drug.  S. Kvåle, K. Dyrstad, T. Jacobsen, O. A. Asbjørnsen and T. Omtveit. Computers chem. Engng. 21, Suppl. S343-S348 (1997).
Read More

3. Chemometrics in pharmaceutical R&D and manufacturing

Farmametri. L. Aanstad, H.R. Bjørsvik, K. Dyrstad, C.P. Tønseth, K. Eivindvik, N.B.Vogt. Kjemi (1996), In memorian proffessor Odd Sergei Borgen.
Read More

2. X-ray, drug administration, injection pressure, DoE, MLR

Relationship between viscosity and determined injection pressure in angiography catheters for common roentgen contrast media. K. Dyvik, K. Dyrstad and A. Tronstad. Acta Radiologica (1995).
Read More

1. Oil migration, ICP, LC, GC, PCA, classification

Experimental simulation of oil migration – Distribution effects on organic compund groups and on metal/metal ratios. T. Greibrokk, E. Lundanes, H.R. Norli, K. Dyrstad and S.D. Olsen. Chemical Geology (1994).
Read More