25. Raw material classification by NIR, PCA, MIPCR (ICA), PLS-DA

Classification of structurally related commercial contrast media by near infrared spectroscopy. Wai Lam Yip, Tom Collin Soosainather, Knut Dyrstad, Sverre Arne Sande Journal of Pharmaceutical and Biomedical Analysis (2013)  
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24. Freeze-drying, crystallization, water content, NIR, PLSR, MIPCR (ICA)

Strategies for multivariate modelling of moisture content in freeze-dried mannitol-containing products by near-infrared spectroscopy. Wai Lam Yip, Ingvil Gausemel, Sverre Arne Sande, Knut Dyrstad Journal of Pharmaceutical and Biomedical Analysis (2012)
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23. Polysorbate oxidation and stability, LC-MS, MR, DoE

Characterization of polysorbate 80 with liquid chromatography mass spectrometry and nuclear magnetic resonance spectroscopy: Specific determination of oxidation products of thermally oxidized polysorbate 80. Erlend Hvattum, Wai Lam Yip, David Grace, Knut Dyrstad Journal of Pharmaceuti
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22. US contrast agent, carbohydrate bubbles, QSAR, PLSR

Stabilization of gas bubbles released from water-soluble carbohydrates using amphiphilic compounds: Preparation of formulations and acoustic monitoring of bubble lifetime. Hoff, L. , Foss, P.A., Dyrstad, K., Klaveness, J., Rongved, P. Journal of Surfactants and Detergents (2011)
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21. PET agent preparation, robustness of 18F-labelling, DoE, MLR

A critical study on borosilicate glassware and silica-based QMA’s in nucleophilic substitution with [18F]fluoride: Influence of aluminum, boron and silicon on the reactivity of [18F]fluoride. Svadberg, A., Clarke, A., Dyrstad, K., Martinsen, I., Hjelstuen, O.K. Applied Radiation
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20. PET, 18F incorporation, DoE, MLR

Site-specific addition of an18F-N-methylaminooxy-containing prosthetic group to a vinylsulfone modified peptide. Olberg, D.E., Hjelstuen, O.K., Solbakken, M., Arukwe, J.M., Dyrstad, K., Cuthbertson, A. Journal of Labelled Compounds and radiopharmaceuticals (2009)
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19. Chemometrics, two-layer (inner, outer) cross validation, PLSR

Reducing over-optimism in variable selection by cross-model validation. Anderssen, E., Dyrstad, K., Westad, F., Martens, H. Chemometrics and Intelligent Laboratory Systems (2006).
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18. Liposomes, controlled release, PLSR

Tuning the MR properties of blood-stable pH-responsive paramagnetic liposomes. L√łkling, K.-E., Skurtveit, R., Dyrstad, K., Klaveness, J., Fossheim, S.L. Int. J. Pharm. (2004).
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17. Preparation of pectin pellets, QSAR, PCA, DoE, PLSR

Quantum chemical descriptors in the formulation of pectin pellets produced by extrusion/spheronisation. Tho, I., Anderssen, E., Dyrstad, K., Kleinebude, K, Sande, S.A. Eur. J. Pharm. Sci. (2002).
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16. Freeze-drying, water content, NIR, PLSR

Sensitive NIRS measurement of increased moisture in stored hygroscopic freeze dried product. A. Stokvold, K. Dyrstad, F.O. Libnau. Journal of Pharmaceutical and Biomedical analysis (2002).
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