28. Development of separation technology for targeted thorium conjugate formulations. Part II, Sequential DOE, MLR, PLS

Development of separation technology for the removal of radium-223 from targeted thorium conjugate formulations. Part II: purification of targeted thorium conjugates on cation exchange columns Janne Olsen Frenvik, Knut Dyrstad, Solveig Kristensen & Olav B. Ryan To cite this artic
Read More

27. Development of Separation Technology for Thorium-227 Conjugate Formulations Part I, DoE, MLR, PLSR

Development of Separation Technology for the Removal of Radium-223 from Targeted Thorium Conjugate Formulations Part I: Purification of Decayed Thorium-227 on Cation Exchange Columns. Janne Olsen Frenvik, Knut Dyrstad, Solveig Kristensen & Olav B. Ryan Published in: Drug Developm
Read More

26. PET Alzheimer agent, formulation, polysorbate solubilser, DoE, MCR, PLSR

The Influence of Polysorbate 80 on the Radiochemical Synthesis of a PET Tracer in the FASTlab Wai Lam Yip, Sverre Arne Sande, David Grace, Dirk Jan In t Veld, Per Christian Sontum, Tina Solvang, Knut Dyrstad Pharm Res 2014 Oct 31. Epub 2014 Oct 31.
Read More

25. Raw material classification by NIR, PCA, MIPCR (ICA), PLS-DA

Classification of structurally related commercial contrast media by near infrared spectroscopy. Wai Lam Yip, Tom Collin Soosainather, Knut Dyrstad, Sverre Arne Sande Journal of Pharmaceutical and Biomedical Analysis (2013)  
Read More

24. Freeze-drying, crystallization, water content, NIR, PLSR, MIPCR (ICA)

Strategies for multivariate modelling of moisture content in freeze-dried mannitol-containing products by near-infrared spectroscopy. Wai Lam Yip, Ingvil Gausemel, Sverre Arne Sande, Knut Dyrstad Journal of Pharmaceutical and Biomedical Analysis (2012)
Read More

23. Polysorbate oxidation and stability, LC-MS, MR, DoE

Characterization of polysorbate 80 with liquid chromatography mass spectrometry and nuclear magnetic resonance spectroscopy: Specific determination of oxidation products of thermally oxidized polysorbate 80. Erlend Hvattum, Wai Lam Yip, David Grace, Knut Dyrstad Journal of Pharmaceuti
Read More

22. US contrast agent, carbohydrate bubbles, QSAR, PLSR

Stabilization of gas bubbles released from water-soluble carbohydrates using amphiphilic compounds: Preparation of formulations and acoustic monitoring of bubble lifetime. Hoff, L. , Foss, P.A., Dyrstad, K., Klaveness, J., Rongved, P. Journal of Surfactants and Detergents (2011)
Read More

21. PET agent preparation, robustness of 18F-labelling, DoE, MLR

A critical study on borosilicate glassware and silica-based QMA’s in nucleophilic substitution with [18F]fluoride: Influence of aluminum, boron and silicon on the reactivity of [18F]fluoride. Svadberg, A., Clarke, A., Dyrstad, K., Martinsen, I., Hjelstuen, O.K. Applied Radiation
Read More

20. PET, 18F incorporation, DoE, MLR

Site-specific addition of an18F-N-methylaminooxy-containing prosthetic group to a vinylsulfone modified peptide. Olberg, D.E., Hjelstuen, O.K., Solbakken, M., Arukwe, J.M., Dyrstad, K., Cuthbertson, A. Journal of Labelled Compounds and radiopharmaceuticals (2009)
Read More

19. Chemometrics, two-layer (inner, outer) cross validation, PLSR

Reducing over-optimism in variable selection by cross-model validation. Anderssen, E., Dyrstad, K., Westad, F., Martens, H. Chemometrics and Intelligent Laboratory Systems (2006).
Read More